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Which one of the following doesn’t help in degrading cohesion?(a) Cdc20(b) M-Cdk(c) Securin(d) SeparaseI have been asked this question during an interview.My question comes from Mitosis Stages Overview in chapter Chromosomal Changes During Meiosis of Cytogenetics

Answer»

The correct choice is (C) Securin

For explanation I would SAY: Securin binds to separase unless it’s BROKEN down by Cdc20. This separase BREAKS down cohesion. The degradation of cohesion is also assisted by M-Cdk as it activates Cdc20. So, among these only securing PREVENTS Cohesin degradation.



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