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Which one of the following is the only active gene in the inactivated X chromosome?(a) XIST(b) XCE(c) Histone coding gene(d) Ribosomal geneThis question was addressed to me by my college director while I was bunking the class.I'm obligated to ask this question of Dosage Compensation Mechanism for X linked Genes in division Chromosomes and Sex Determination of Cytogenetics

Answer»

The correct answer is (a) XIST

The best I can EXPLAIN: The X inactive SPECIFIC transcript (XIST in humans/ Xist in mice) gene, is located in the XIC, it’s expressed exclusively from the inactive X chromosome, PRODUCING a 17 kb non-coding RNA that is not translated. Ribosome GENES are in nucleolus.



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