Which one of these is not an approach to make the drug cross the blood-brain barrier?(a) Using permeation enhancers(b) Osmotic disruption of the blood-brain barrier(c) Use of highly lipophilic drug only(d) Use of drug carriers to cross the BBBThe question was asked during an internship interview.My question comes from Drug Distribution topic in chapter Distribution of Drugs of Drug Biotechnology

Which one of these is not an approach to make the drug cross the blood

1.	Which one of these is not an approach to make the drug cross the blood-brain barrier?(a) Using permeation enhancers(b) Osmotic disruption of the blood-brain barrier(c) Use of highly lipophilic drug only(d) Use of drug carriers to cross the BBBThe question was asked during an internship interview.My question comes from Drug Distribution topic in chapter Distribution of Drugs of Drug Biotechnology
Answer» The correct choice is (c) Use of highly LIPOPHILIC drug only Best explanation: Three different approaches that have been used to PROMOTE crossing the BBB is the use of permeation enhancers such as DMSO, osmotic disruption of the BBB by infusing internal carotid ARTERY with MANNITOL, Use of dihydropyridine redox system as drug CARRIERS to the brain.

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