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Which organs comprise the central compartment in a two compartment model?(a) Muscles(b) Skin(c) Adipose(d) LiverI have been asked this question during an online interview.This key question is from One & Two Compartment Open Model topic in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer» RIGHT answer is (d) LIVER

Explanation: The central COMPARTMENT or the compartment 1 in a two compartment model comprises of the blood and the HIGHLY perfused tissues like liver, lungs, and kidneys, etc. which equilibrate blood RAPIDLY. These compartments will have the elimination from them.


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