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Which type of drug cannot enter the cell membrane in the below picture?(a) Ionized drug(b) Unionized drug(c) Hydrolyzed drug(d) Unhydrated drugI got this question during an interview.This interesting question is from Drug Distribution in portion Distribution of Drugs of Drug Biotechnology

Answer» CORRECT choice is (a) Ionized DRUG

The BEST I can explain: Most DRUGS are weak acids or weak bases. And their degree of ionization at plasma pH DEPENDS upon their pKa. Here the drug has shown which cannot enter the cell membrane is the ionized drug.


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