A mediator helps to connect ___________(a) Enhancer to DPE(b) Silencer to Enhancer(c) Enhancer to TAF(d) Insulator to silencerI got this question in an international level competition.My question is from Transcription in Eukaryotes : Transcription Factors in division Gene Expression : Transcription Prokaryotes of Cytogenetics

A mediator helps to connect ___________(a) Enhancer to DPE(b) Silencer

1.	A mediator helps to connect ___________(a) Enhancer to DPE(b) Silencer to Enhancer(c) Enhancer to TAF(d) Insulator to silencerI got this question in an international level competition.My question is from Transcription in Eukaryotes : Transcription Factors in division Gene Expression : Transcription Prokaryotes of Cytogenetics
Answer» The CORRECT CHOICE is (c) Enhancer to TAF The best I can explain: As enhancer elements work from a distance the CONNECTING DNA is often looped and the enhancer connects to the RNA pol bound TAF through a mediator. A silencer may connect to TAF in a similar way.

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