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Which of these SIR proteins are having HDAC activity?(a) SIR1(b) SIR2(c) SIR3(d) SIR4I got this question during a job interview.This intriguing question originated from Transcription in Eukaryotes : Gene Silencing at Telomere topic in portion Gene Expression : Transcription Prokaryotes of Cytogenetics

Answer»

The correct option is (b) SIR2

To elaborate: The SIR or silent INFORMATION regulator PROTEINS are responsible for repression at the telomere by deacetylating the histones. While SIR3and SIR4 BIND to the N-termini the SIR2 protein which is attracted by SIR 3-4 is having the HDAC ACTIVITY.



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