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Akt doesn’t phosphorylate ________________(a) Bad(b) FOXO(c) Gsk -3(d) CaspasesThis question was posed to me in an interview for job.Asked question is from Apoptosis and Cancer in portion Cancer Biology & Methods in Cytogenetics of Cytogenetics

Answer»

Right choice is (d) Caspases

To EXPLAIN: Akt is an inhibitory src kinase that is activated DOWNSTREAM of anti- apoptotic pathway. This phosphorylates bad and FOXO generating 14-3-3 protein BINDING SITE, and also phosphorylates Gsk-3. But it doesn’t phosphorylate caspases.



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