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Which one of the following acts as CKI?(a) P20(b) p27(c) p35(d) p53The question was asked in an interview for internship.I need to ask this question from Cell Cycle Stages in portion Cancer Biology & Methods in Cytogenetics of Cytogenetics

Answer»

Right choice is (B) p27

The explanation is: p27 can bind to the CDK-cyclin complex in a way that the catalytic site is no LONGER able to interact with the substrate. This leads to inactivation; THUS, it’s a CDK INHIBITORY protein or CKI.



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