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P53 accumilation activates which polymerase to repair DNA damage?(a) Pol alpha(b) Pol Beta(c) Pol kappa(d) Pol etaI got this question in exam.My doubt stems from Apoptosis and Cancer topic in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics

Answer»

Correct option is (c) Pol kappa

To explain I would say: On sensing the DNA damage p53 level rises which stimulate GADD45 and pol K which tries to REPAIR the DNA damage. Only when the damage is too much to repair apoptosis is TRIGGERED.



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