Cell with DNA damage via a series of protein kinases__________(a) Activates CDC25(b) Inactivated CDC25(c) Activates WEE1(d) Inactivates WEE1This question was addressed to me in an interview for job.This intriguing question comes from Cell Cycle Stages in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics

Cell with DNA damage via a series of protein kinases__________(a) Acti

1.	Cell with DNA damage via a series of protein kinases__________(a) Activates CDC25(b) Inactivated CDC25(c) Activates WEE1(d) Inactivates WEE1This question was addressed to me in an interview for job.This intriguing question comes from Cell Cycle Stages in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics
Answer» Correct option is (b) INACTIVATED CDC25 The explanation: CDC25 is a phosphatase that removes the inhibitory phosphate on the S Cycin-CDk complex that leads to the activation. WEE1 kinase ADDS this phosphate leading to inactivation. DNA damage requires sop of cell CYCLE thus CDC2 which helps in progression is inactivated.

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