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Cyclin binding leads to a change in the _________________ of kinase.(a) pH(b) temperature(c) concentration(d) conformationI got this question in an interview.The doubt is from Cellular Reproduction in chapter DNA Replication and Repair, Cellular Reproduction of Cell Biology

Answer»

Right answer is (d) conformation

To explain I would SAY: Cyclin binding leads to a change in the conformation of catalytic SUBUNIT of kinase enzyme by binding to its catalytic SITE. This binding allows the cyclin dependent kinase (CDK) to PHOSPHORYLATE its SUBSTRATES.



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