Displacement interactions are significant in the case of drugs which are more than 95% bound.(a) True(b) FalseI got this question by my college professor while I was bunking the class.Query is from Factors Affecting Protein Drug Binding topic in portion Protein Binding of Drugs of Drug Biotechnology

Displacement interactions are significant in the case of drugs which a

1.	Displacement interactions are significant in the case of drugs which are more than 95% bound.(a) True(b) FalseI got this question by my college professor while I was bunking the class.Query is from Factors Affecting Protein Drug Binding topic in portion Protein Binding of Drugs of Drug Biotechnology
Answer» Correct choice is (a) True Easy EXPLANATION: A displacement of 1% and 99% bound drug RESULTS in doubling of the FREE drug concentration i.e. a 100% rise. For a drug which is bound to 99% and a displacement of 1% results in only a 10% rise in FREED rug concentration which may be insignificant clinically.

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