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Which of the following drugs are responsible for retinopathy?(a) Acidic drugs like imipramine(b) Basic drugs like imipramine(c) Halogenated hydrocarbons(d) ChloroquinineI have been asked this question during an online exam.This interesting question is from Tissue Binding of Drugs in portion Protein Binding of Drugs of Drug Biotechnology

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Right answer is (d) Chloroquinine

For explanation I would say: Chloroquine and phenothiazines accumulate in skin by interacting with melanin.Since our RETINAL pigment of eye also has melanin, BINDING of chloroquine and phenothiazines to it is RESPONSIBLE for retinopathy.



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