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Which one of the following is the correct order of the drugs binding to various plasma protein?(a) Albumin > alpha-1 acid glycoprotein > globulins> lipoproteins(b) Albumin > globulins> lipoproteins > alpha-1 acid glycoprotein(c) Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins(d) Albumin > lipoproteins> globulins> alpha-1 acid glycoproteinI got this question during an interview.I would like to ask this question from Plasma Protein Drug Binding in portion Protein Binding of Drugs of Drug Biotechnology

Answer» RIGHT option is (c) Albumin > alpha-1 acid glycoprotein > LIPOPROTEINS > globulins

Explanation: The binding of the drug to the PLASMA protein is reversible. The extent of the binding is in the FOLLOWING order albumin > alpha-1 acid glycoprotein > lipoproteins > globulins. Drugs of all types, varieties can EASILY bind to the Human serum albumin.


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