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Which one of the following is the correct order of the drugs binding to various plasma protein?(a) Albumin > alpha-1 acid glycoprotein > globulins> lipoproteins(b) Albumin > globulins> lipoproteins > alpha-1 acid glycoprotein(c) Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins(d) Albumin > lipoproteins> globulins> alpha-1 acid glycoproteinI got this question during an interview.I would like to ask this question from Plasma Protein Drug Binding in portion Protein Binding of Drugs of Drug Biotechnology |
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Answer» RIGHT option is (c) Albumin > alpha-1 acid glycoprotein > LIPOPROTEINS > globulins Explanation: The binding of the drug to the PLASMA protein is reversible. The extent of the binding is in the FOLLOWING order albumin > alpha-1 acid glycoprotein > lipoproteins > globulins. Drugs of all types, varieties can EASILY bind to the Human serum albumin. |
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