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Which of the following drugs accumulate in skin?(a) Acidic drugs like imipramine(b) Basic drugs like imipramine(c) Halogenated hydrocarbons(d) ChloroquineI got this question in an international level competition.My question is taken from Tissue Binding of Drugs topic in chapter Protein Binding of Drugs of Drug Biotechnology |
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Answer» CORRECT option is (d) CHLOROQUINE To elaborate: Skin as melanin which PROTECTS US from the harmful UV rays of the sun. Chloroquine and phenothiazines accumulate in skin by INTERACTING with melanin. |
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