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ESE bound to SR proteins ______________ splicing and ESE bound to hnRNA ______________ splicing.(a) Activate, activate(b) Activate, inactivate(c) Inactivate, activate(d) Inactivate, inactivateThe question was posed to me in semester exam.This interesting question is from Post-Transcriptional Modification in section Gene Expression : Transcription Prokaryotes of Cytogenetics

Answer»

Correct answer is (b) Activate, inactivate

Easy explanation: Binding of SR proteins to ESE or exon splicing ENHANCERS promotes splicing where that exon is retained. hnRNA is a competitive inhibitor of SR proteins that tend to bind ESE as well, thus it INACTIVATES.



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