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Histones are __________(a) Neutral(b) Positively charged(c) Negatively charged(d) Neutral with positive and negative domainsI have been asked this question in an internship interview.This is a very interesting question from Transcription in Eukaryotes : Chromatin Remodelling in section Gene Expression : Transcription Prokaryotes of Cytogenetics

Answer» CORRECT answer is (B) Positively charged

The explanation: HISTONES are rich in positively charged amino acids namely lysine and arginine. Thus they have a net POSITIVE charge. This helps them to bind to the negatively charged DNA.


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