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How does NSAIDs work?(a) Inhibit arachidonic acid(b) Inhibit Endoperoxide intermediate(c) Inhibit Prostaglandin and thromboxane synthesis(d) Inhibit cyclooxygenaseI have been asked this question in an international level competition.My doubt stems from Drug Addiction and Abuse topic in section Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

Answer»

The correct option is (d) Inhibit cyclooxygenase

Easiest explanation: All NSAIDs inhibit the cyclooxygenase required for the conversion of arachidonic acid to endoperoxide intermediate (PGG2 and PGH2). NSAIDs inhibit prostaglandin and THROMBOXANE synthesis, they are potent inhibitors of cyclooxygenase and eliminate all prostaglandins and thromboxanes in EVERY cell they reach. The key enzyme in the cyclooxygenase pathway is the enzyme cyclooxygenase (COX). There are two FORMS of cyclooxygenase, COX1 (the predominant form) and COX2.



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