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Which of the following is also known as “housekeeping enzyme”?(a) COX 1(b) COX 2(c) COX 3(d) COX 4I got this question in homework.The above asked question is from Drug Addiction and Abuse in section Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

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Correct ANSWER is (a) COX 1

To explain: Cyclooxygenase-1 (COX-1) constitutively EXPRESSED in a wide variety of cells all over the body and THUS known as “housekeeping enzyme” e.g.Gastric cytoprotection. Cyclooxygenase-2 (COX-2), INDUCIBLE enzyme an immediate-early gene product in inflammatory and immune cells it is DRAMATICALLY up-regulated during inflammation.



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