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Which of the following has the least GI effect and derived from parent NSAIDs?(a) Piroxicam(b) Phenylbutazone(c) NO-NSAIDs(d) IndomethacinThe question was asked in an interview for job.The doubt is from Drug Addiction and Abuse topic in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

Answer»

The correct answer is (c) NO-NSAIDs

To ELABORATE: Nitric oxide-releasing NSAIDs. It has fewer GI effects than PARENT NSAID from which they are derived. It has a comparable anti-inflammatory EFFECT and superior analgesic effect. The parent NSAID is Naproxen. The possible mechanism can be that nitric oxide IMPROVES gastric blood FLOW.



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