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Which of the following is amide type drug?(a) Lignocaine(b) Cocaine(c) Procaine(d) BenzocaineThe question was posed to me in an international level competition.This intriguing question originated from Mechanism of Action of Local Anesthetic in division Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

Answer»

The CORRECT answer is (a) Lignocaine

For explanation I would say: Benzocaine, procaine, and cocaine are ester type DRUGS. Procaine is used in dentistry when the PATIENTS have proven allergy to the amide group. Lignocaine is an amide-type drug. It is HIGHLY lipophilic and rapidly absorbed.



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