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Which is the first local anesthetic?(a) Cocaine(b) Benzocaine(c) Benzyl alcohol(d) Clove oilI got this question in an internship interview.Enquiry is from Mechanism of Action of Local Anesthetic in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

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Correct CHOICE is (a) Cocaine

For explanation: The first and most potent LOCAL anesthetic agent is cocaine though it is rarely used now used because of the problems of misuse. It is unique in it is the ability to produce intense vasoconstriction. The half-life of cocaine is 30 minutes. Dosage of cocaine when used as topical ADMINISTRATION 4 – 10% solution of cocaine.



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