In mice if you delete the Igf2 gene from a female, the progeny will_____________(a) Be smaller(b) Die(c) No major change(d) Be largerThe question was posed to me in an internship interview.Question is from Silencing and Genomic Imprinting topic in portion Regulating Gene Expression in Eukaryotes of Cytogenetics

In mice if you delete the Igf2 gene from a female, the progeny will___

1.	In mice if you delete the Igf2 gene from a female, the progeny will_____________(a) Be smaller(b) Die(c) No major change(d) Be largerThe question was posed to me in an internship interview.Question is from Silencing and Genomic Imprinting topic in portion Regulating Gene Expression in Eukaryotes of Cytogenetics
Answer» The CORRECT option is (c) No major change For explanation: In mice the IGF2 genes from the female parent is methylated and inactivated by imprinting and only the male one is expressed. THUS, ABSENCE of the respective gene in mother shows no significant effect. However, if it were male hen the PROGENY would be smaller.

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