1.

Which of the following is incorrect for Pader will syndrome?(a) This is due to failure of inheritance of several non-imprint genes(b) It is seen for chromosome 15(c) It causes loss of active genes in 15q11-q13(d) It occurs when the region containing specific genes in the maternal chromosome are missingI had been asked this question in unit test.The above asked question is from Silencing and Genomic Imprinting topic in chapter Regulating Gene Expression in Eukaryotes of Cytogenetics

Answer»

Right choice is (d) It occurs when the region containing SPECIFIC genes in the maternal chromosome are missing

For explanation: In case of PADER Willi SYNDROME the genes 15q11-q13 contained in the paternal chromosome are missing which LEADS to the defects. It is not DUE to the maternal factors missing.



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