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Neurofibrilomatosis varies in ________________(a) Penetrance(b) Expressivity(c) Both penetrance and expressivity(d) It is 100% penetrant and expressiveThe question was posed to me at a job interview.Question is taken from Penetrance and Expressivity topic in chapter Regulating Gene Expression in Eukaryotes of Cytogenetics

Answer» CORRECT option is (c) Both penetrance and expressivity

To explain: NEUROFIBRILOMATOSIS is an autosomal dominant trait that causes tumour lie growth all over the body. It is 50-80% PENETRANT and varies in expressivity.


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