1.

P53 has a high turnover number.(a) True(b) FalseThe question was posed to me during an interview.This intriguing question comes from Apoptosis and Cancer topic in division Cancer Biology & Methods in Cytogenetics of Cytogenetics

Answer»

Right OPTION is (a) True

The EXPLANATION: In the normal CELL p53 can interact with Mdm2 which acts as specific E3 ubiquitin ligase for p53 and ubiquitination leads to destruction of p53. It thus has a high TURNOVER number and doesn’t accumulate in healthy cells.



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