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Rho shows base preference although it doesn’t have any concensus cis binding sequence. Which region will be expected to bind Rho better?(a) G and C rich region(b) A and T rich region(c) Region rich in C and poor in G(d) Region rich in A and poor in TThe question was posed to me during an interview for a job.Question is taken from Transcription in Prokaryotes : Termination topic in division Gene Expression : Transcription Prokaryotes of Cytogenetics

Answer»

The correct choice is (c) Region RICH in C and POOR in G

For explanation I would say: RHO binds BEST to regions having high C CONTENT as much as 41% and low G content as much as 14%. As in RNA there is no compulsory base pairing the amount of G is not necessary equal to the amount of c.



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