We know that region 2.4 of sigma factor binds DNA at -10box. What is the function of 2.1?(a) It is a flexible loop with no known function(b) It binds -35box(c) It binds RNA polymerase(d) It binds region 4.1 to give sigma its specific structure and functionI had been asked this question in an interview.My question is taken from Transcription in Prokaryotes : Sigma Factor topic in section Gene Expression : Transcription Prokaryotes of Cytogenetics

We know that region 2.4 of sigma factor binds DNA at -10box. What is t

1.	We know that region 2.4 of sigma factor binds DNA at -10box. What is the function of 2.1?(a) It is a flexible loop with no known function(b) It binds -35box(c) It binds RNA polymerase(d) It binds region 4.1 to give sigma its specific structure and functionI had been asked this question in an interview.My question is taken from Transcription in Prokaryotes : Sigma Factor topic in section Gene Expression : Transcription Prokaryotes of Cytogenetics
Answer» Right CHOICE is (C) It BINDS RNA POLYMERASE The EXPLANATION: Region 2.1 helps to bind the sigma factor to the RNA polymerase. The binding is not absolute as this factor is dissociable. -35box on the other hand is recognized by region 4.2.

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