What reasons make tissue-drug binding important for drug distribution?(a) Increases the volume of distribution of drugs and results in localization of drug at a specific site(b) Increases the volume of distribution of drugs(c) Results in localization of drugs at a tissue specific site(d) Increases in absorption from the tissue due to concentration increasingI had been asked this question in class test.This intriguing question originated from Tissue Binding of Drugs topic in chapter Protein Binding of Drugs of Drug Biotechnology

What reasons make tissue-drug binding important for drug distribution?

1.	What reasons make tissue-drug binding important for drug distribution?(a) Increases the volume of distribution of drugs and results in localization of drug at a specific site(b) Increases the volume of distribution of drugs(c) Results in localization of drugs at a tissue specific site(d) Increases in absorption from the tissue due to concentration increasingI had been asked this question in class test.This intriguing question originated from Tissue Binding of Drugs topic in chapter Protein Binding of Drugs of Drug Biotechnology
Answer» Correct CHOICE is (a) Increases the volume of distribution of drugs and RESULTS in localization of DRUG at a specific SITE For EXPLANATION: Tissue-drug binding is important in the distribution of drugs. This is because it increases the apparent volume of distribution of drugs in contrast to plasma protein which decreases it. Tissue-drug binding results in localization of the drug at a specific site in the body.

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