When sigma subunit dissociates from the RNA polymerase what happens to the DNA binding clamp of the core?(a) It opens again(b) It closes again(c) It enters a semi open stage(d) It is phophorylated and ubiquitination occursI got this question in final exam.My query is from Transcription in Prokaryotes : Sigma Factor topic in section Gene Expression : Transcription Prokaryotes of Cytogenetics

When sigma subunit dissociates from the RNA polymerase what happens to

1.	When sigma subunit dissociates from the RNA polymerase what happens to the DNA binding clamp of the core?(a) It opens again(b) It closes again(c) It enters a semi open stage(d) It is phophorylated and ubiquitination occursI got this question in final exam.My query is from Transcription in Prokaryotes : Sigma Factor topic in section Gene Expression : Transcription Prokaryotes of Cytogenetics
Answer» RIGHT option is (d) It is phophorylated and ubiquitination occurs Easiest explanation: In the ABSENCE of the sigma SUBUNIT initially the RNA Pol clamp is closed. Sigma makes a WINDOW of open clamp conformation when RNA pol loads on the DNA. When sigma dissociates the clamp closes again AROUND the DNA preventing the pol to fall off.

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