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Which caspase is activated in the ER pathway of apoptosis?(a) Caspase 3(b) Caspase 7(c) Caspase 8(d) Caspase 12This question was addressed to me in an online interview.The origin of the question is Apoptosis and Cancer in section Cancer Biology & Methods in Cytogenetics of Cytogenetics

Answer»

Right option is (d) CASPASE 12

Best explanation: In extreme hypoxic CONDITIONS, the TRAF2 in the ER RELEASES the associated PROCASPASE 12; activated caspase 12 and leads to apoptosis.



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