Which DNA binding domain is seen in region 4.2 of sigma factor?(a) Zinc fingers(b) Helix turn helix(c) Leucine zipper(d) Beta barrelThis question was posed to me in an interview.This is a very interesting question from Transcription in Prokaryotes : Sigma Factor in section Gene Expression : Transcription Prokaryotes of Cytogenetics

Which DNA binding domain is seen in region 4.2 of sigma factor?(a) Zin

1.	Which DNA binding domain is seen in region 4.2 of sigma factor?(a) Zinc fingers(b) Helix turn helix(c) Leucine zipper(d) Beta barrelThis question was posed to me in an interview.This is a very interesting question from Transcription in Prokaryotes : Sigma Factor in section Gene Expression : Transcription Prokaryotes of Cytogenetics
Answer» The correct answer is (b) Helix turn helix Best explanation: Region 4.2 of sigma subunit has a helix turn helix MOTIF that HELPS it to bind to the major groove of DNA. The SIMILAR motif has been SEEN in region 3 as well. Zinc fingers and leucine zipper are examples of other DNA BINDING motif.

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