Which drug easily bind to AAG?(a) Cationic drug(b) Anionic drug(c) Lipophilic drug(d) Neutral drugI have been asked this question during an interview.This is a very interesting question from Factors Affecting Protein Drug Binding topic in division Protein Binding of Drugs of Drug Biotechnology

Which drug easily bind to AAG?(a) Cationic drug(b) Anionic drug(c) Lip

1.	Which drug easily bind to AAG?(a) Cationic drug(b) Anionic drug(c) Lipophilic drug(d) Neutral drugI have been asked this question during an interview.This is a very interesting question from Factors Affecting Protein Drug Binding topic in division Protein Binding of Drugs of Drug Biotechnology
Answer» Right option is (a) Cationic drug The EXPLANATION is: ANIONIC or acidic drugs bind to HSA easily. Cationic or basic drugs having negative charge can bind easily to alpha 1 acid glycoprotein, for example, IMIPRAMINE and alprenolol. Neutral and unionized drugs bind to lipoproteins. Lipophilic drugs localize more into adipose TISSUE.

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