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Which of the following association acts as transcriptional activator?(a) Myc- Max(b) Mad- Max(c) Map- Mad(d) MapK- MycI had been asked this question in an international level competition.My question is taken from Transcription in Eukaryotes : Chromatin Remodelling topic in section Gene Expression : Transcription Prokaryotes of Cytogenetics

Answer» RIGHT ANSWER is (a) Myc- MAX

The EXPLANATION: When Max associates with Myc the gene is transcriptionally active, while when Max associates with Mad the gene is inactivated. This is because Mad binds to SIN3A which brings about a HDAC.


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