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Which of the following Cdk is resistant to Hct1?(a) G1(b) G1-S(c) Both G1 and G1-S(d) G1, G1 S and SI have been asked this question during an online exam.This intriguing question comes from Cell Cycle Stages in section Cancer Biology & Methods in Cytogenetics of Cytogenetics

Answer»

Right choice is (c) Both G1 and G1-S

The best I can explain: The G1 Cdk is RESPONSIBLE for the re-initiation of the cell cycle, this is done by the process that G1 Cdk is resistant to Hct1, it TRANSCRIBES G1-S. Thus EVEN in G1 phase when the Hct1 concentration is high it can be ACTIVATED. G1-S CYCLIN phosphorylates and inactivates Hct1.



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