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Which of the following gives a negative signal during anaphase?(a) Cdc25(b) Wee1(c) P53(d) Mad 2I got this question in an interview for internship.I'd like to ask this question from Cell Cycle Stages in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics

Answer»

Right choice is (d) Mad 2

For explanation: Mad 2 bind to the kinetochores that are not BOUND to the SPINDLE fibers. This is a negative signal. Removal of this negative feedback leads to anaphase.



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