Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.(a) CuC(b) C / Cu(c) Cu/C(d) 1/C CuI got this question in examination.My question is taken from Factors Affecting Protein Drug Binding topic in portion Protein Binding of Drugs of Drug Biotechnology

Which of the following is a correct method to find the fraction of unb

1.	Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.(a) CuC(b) C / Cu(c) Cu/C(d) 1/C CuI got this question in examination.My question is taken from Factors Affecting Protein Drug Binding topic in portion Protein Binding of Drugs of Drug Biotechnology
Answer» The CORRECT choice is (c) Cu/C To explain I would SAY: The fraction of unbound drug can be CALCULATED with the formula fu = Cu/C, where Cu is the CONCENTRATION of unbound drug and C is TOTAL plasma drug concentration and fu is the unbound drug.

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