Which of the following is not a normal modification of the rRNA primary transcript?(a) Conversion of U base to Pseudo uridine(b) Methylation of the 2’- OH region of specific rRNA bases(c) Cleavage of the intervening regions by exonucleases(d) Proteins modulating the cleavageThis question was posed to me in a job interview.This is a very interesting question from RNA Processing Control in portion Regulating Gene Expression in Eukaryotes of Cytogenetics

Which of the following is not a normal modification of the rRNA primar

1.	Which of the following is not a normal modification of the rRNA primary transcript?(a) Conversion of U base to Pseudo uridine(b) Methylation of the 2’- OH region of specific rRNA bases(c) Cleavage of the intervening regions by exonucleases(d) Proteins modulating the cleavageThis question was posed to me in a job interview.This is a very interesting question from RNA Processing Control in portion Regulating Gene Expression in Eukaryotes of Cytogenetics
Answer» Right choice is (d) Proteins modulating the cleavage To EXPLAIN: In CASE of rRNA the SNORNA along with proteins making snoRNP aids in cleavage and modifications, and not just proteins as seen in case of tRNA primary TRANSCRIPT.

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