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Which of the following ubiquitin ligase concentration is regulated for proper cell cycle progression?(a) E1(b) E2(c) E3(d) E4I have been asked this question in exam.The origin of the question is Cell Cycle Stages in section Cancer Biology & Methods in Cytogenetics of Cytogenetics

Answer»

Correct choice is (c) E3

To explain: E3 ubiquitin ligase is finally responsible for adding the POLY ubiquitin tail to the SUBSTRATE to MARK it for destruction. Thus regulating the E3 level will help to regulate the concentration of the substrate.



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