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Which of these interactions is the weakest?(a) rC-dG(b) rG-dC(c) rA-dT(d) rU-dAI got this question during an internship interview.This question is from Transcription in Prokaryotes : Termination topic in division Gene Expression : Transcription Prokaryotes of Cytogenetics

Answer»

The CORRECT answer is (d) rU-dA

For explanation I would say: The interaction between A and T or U base is through 2 HYDROGEN bonds only. So this is weaker than G-C which mediates by 3 hydrogen bonds. Further RNA DNA INTERACTIONS are weaker making rU-dA the weakest of interaction which is used in termination of TRANSCRIPTION.



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