Which of this element is not orientation independent?(a) Enhancer(b) Silencer(c) Upstream activating element(d) Promoter proximal elementsThe question was asked in a job interview.My question comes from Transcription in Eukaryotes : Activators and Repressors in division Gene Expression : Transcription Prokaryotes of Cytogenetics

Which of this element is not orientation independent?(a) Enhancer(b) S

1.	Which of this element is not orientation independent?(a) Enhancer(b) Silencer(c) Upstream activating element(d) Promoter proximal elementsThe question was asked in a job interview.My question comes from Transcription in Eukaryotes : Activators and Repressors in division Gene Expression : Transcription Prokaryotes of Cytogenetics
Answer» Right ANSWER is (d) PROMOTER PROXIMAL elements The best I can explain: While upstream ACTIVATING ELEMENT is orientation independent, enhancers and silencers are position as well as orientation independent. On the other hand promoter proximal elements are orientation dependent.

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