1.

Which of this is untrue about TBP?(a) It is a part of TFIID(b) It makes a kink in the DNA(c) It is orientation independent(d) It is sequence independentThe question was asked in a job interview.My enquiry is from Transcription in Eukaryotes : Transcription Factors topic in chapter Gene Expression : Transcription Prokaryotes of Cytogenetics

Answer»

Correct choice is (d) It is sequence independent

Best explanation: TBP specifically recognizes and BINDS to TATA consensus sequence which makes it sequence dependent. Its correct ORIENTATION is HOWEVER determined by other factors like TFIIA and TFIIB. It makes an 80 KINK in the DNA and is a part of TFIID.



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