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Which part of cholesterol molecule is not embedded in the lipid bilayer?(a) Hydroxyl end of cholesterol(b) Entire molecule of cholesterol(c) Hydrophobic rings(d) Hydroxyl end and ^1⁄4th of the hydrophobic ringsI have been asked this question by my college professor while I was bunking the class.My query is from Chemical Composition of Membranes topic in section Cellular Membranes of Cell Biology

Answer»

Correct ANSWER is (a) Hydroxyl end of cholesterol

The best explanation: Cholesterol MOLECULES are oriented with their SMALL hydrophilic hydroxyl groups TOWARD the membrane surface and the remainder of molecule embedded in LIPID bilayer. The hydrophilic rings of a cholesterol molecule are flat and rigid and interfere with the fatty acid tails of phospholipids.



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