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51.

The XXY klinefelter survive but trisomy in most autosome is lethal. Why?(a) Autosome carries more genes(b) Autosomes have better dominant recessive relations(c) X chromosomes are inactivated(d) Autosomes are more in numberThe question was posed to me in an online interview.This interesting question is from Dosage Compensation Mechanism for X linked Genes in division Chromosomes and Sex Determination of Cytogenetics

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Right choice is (c) X chromosomes are inactivated

To explain: Due to dosage COMPENSATION only ONE X CHROMOSOME in XXY says active. So the EFFECT of excess X chromosome is somewhat mitigated. In autosome there is no such inactivation and excess of GENE products leads to lethality.

52.

Which one of the following is the only active gene in the inactivated X chromosome?(a) XIST(b) XCE(c) Histone coding gene(d) Ribosomal geneThis question was addressed to me by my college director while I was bunking the class.I'm obligated to ask this question of Dosage Compensation Mechanism for X linked Genes in division Chromosomes and Sex Determination of Cytogenetics

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The correct answer is (a) XIST

The best I can EXPLAIN: The X inactive SPECIFIC transcript (XIST in humans/ Xist in mice) gene, is located in the XIC, it’s expressed exclusively from the inactive X chromosome, PRODUCING a 17 kb non-coding RNA that is not translated. Ribosome GENES are in nucleolus.

53.

A colorblind mother and a normal father give birth to a Klinefelter child with normal vision. Where do you think the non-disjunction has taken place?(a) 1^st meiotic division of mother(b) 2^nd meiotic division of the father(c) 2^nd meiotic division of mother(d) 1^st meiotic division of fatherI have been asked this question in unit test.My query is from Sex Linked Inheritance in chapter Chromosomes and Sex Determination of Cytogenetics

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The correct option is (d) 1^st meiotic division of father

For EXPLANATION I would say: The non DISJUNCTION must be in the male parent as the child was not COLOR blind. This is possible only if one X chromosome was normal which here came from father. ALSO as the disjunction produced XY and not two copies of same chromosome it must have been in 1^st division.

54.

A female with AA+ XXX can only result from female parental non-disjunction.(a) True(b) FalseI have been asked this question in examination.This key question is from Sex Determination in Mammals in section Chromosomes and Sex Determination of Cytogenetics

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The correct answer is (b) False

Easiest EXPLANATION: Both 1^st and 2^nd MEIOTIC non-disjunction in female can give AA+ XXX combination. Also 2^nd meiotic non-disjunction in male gamete where two X chromosome moves to same pole can also give this result.

55.

Appearance of cock feather in chicken is ________________(a) X linked(b) Y linked(c) Sex influenced(d) Sex limitedThis question was posed to me during an online interview.This interesting question is from Sex Influenced Traits and Sex Limited Traits in chapter Chromosomes and Sex Determination of Cytogenetics

Answer» RIGHT option is (d) Sex limited

To explain: This GENE is LOCATED in the autosome so it’s not X or Y linked. Cock FEATHERING will not be seen in hen even when it is HOMOZYGOUS, hence it’s not sex influenced. Thus, it is sex limited trait.
56.

Calico cats are always______________(a) Male(b) Female(c) Klinefelter(d) TurnerI got this question in an online quiz.This intriguing question comes from Dosage Compensation Mechanism for X linked Genes topic in chapter Chromosomes and Sex Determination of Cytogenetics

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Right option is (b) Female

To elaborate: In CALICO cats there is development of black and orange and white patches. This is POSSIBLE only when the dominant O allele is turned off in some X chromosome DUE to DOSAGE compensation. As males have only one X chromosome they are never turned off. THUS, only females show this trait.

57.

Which of the following is partially sex linked?(a) Complete colorblindness(b) Hypertrichosis(c) Faulty tooth enamel(d) HaemophiliaThe question was asked during an interview.I'm obligated to ask this question of Sex Linked Inheritance topic in section Chromosomes and Sex Determination of Cytogenetics

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Correct option is (a) Complete colorblindness

To explain I would say: While red green colorblindness is an X linked recessive TRAIT. Complete colorblindness HOWEVER is a PARTIALLY sex linked GENE in man.

58.

A person with a genetic composition AA+XYY composition. The non-disjunction is in the __________ parent and in _____________ meiotic division.(a) Male, 1st(b) Male, 2nd(c) Female, 1st(d) Female, 2ndThis question was posed to me in a national level competition.This intriguing question comes from Sex Determination in Mammals topic in division Chromosomes and Sex Determination of Cytogenetics

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Right choice is (b) Male, 2ND

The explanation is: A female can never have Y chromosome to start with so the non-disjunction is in a male. If the non-disjunction was in 1st DIVISION improper segregation of X and Y will produce XY gamete. Here there is an improper 2nd division where 2Y generated in meiosis 2 moves to same POLE giving YY gamete.

59.

Human being with genetic combination AA+ XXX will be non-viable like Drosophila with the same combination.(a) True(b) FalseI have been asked this question by my school principal while I was bunking the class.The origin of the question is Sex Determination in Mammals topic in chapter Chromosomes and Sex Determination of Cytogenetics

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The correct ANSWER is (b) False

The explanation is: In HUMAN beings unlike drosophila there is dosage compensation for the extra X chromosome. DUE to this reason this person will be a viable female.

60.

Which of the following is wrong for sex chromosome?(a) X chromosome is larger than Y(b) Female human are homozygous(c) Y chromosome carries TDF(d) All genes present on Y chromosome are unique to itI had been asked this question during an interview for a job.This intriguing question originated from Sex Determination in Mammals in portion Chromosomes and Sex Determination of Cytogenetics

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Right CHOICE is (d) All GENES present on Y chromosome are unique to it

The explanation: There is a homologous region between the X and Y chromosome, and genes in Y chromosome in that area is not unique to it. TDF is another NAME used for SRC gene that is also located on Y chromosome.

61.

In bees the males are produced by _________(a) Mitosis and then fertilization(b) Meiosis and then fertilization(c) Mitosis but no fertilization(d) Meiosis but no fertilizatonI have been asked this question by my college professor while I was bunking the class.Question is taken from Other Methods of Sex Determination topic in division Chromosomes and Sex Determination of Cytogenetics

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Right choice is (C) Mitosis but no fertilization

For EXPLANATION: Bees have XO system of sex determination. In it the MALES are produced by parthenogenesis i.e. here is mitosis occurring in the mother that GIVES the zygote for male offspring.

62.

In ZZ/ZW system if there is a recessive Z allele carrying a distinct phenotype, it will have greater probability of expression in ____________(a) Male(b) Female(c) Recessive genes will not be expressed(d) Both genders equallyI had been asked this question by my school teacher while I was bunking the class.This intriguing question originated from Other Methods of Sex Determination topic in division Chromosomes and Sex Determination of Cytogenetics

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The CORRECT option is (b) Female

To explain I would say: Females being heterozygous will lack the compensating functional copy from other Z chromosomes will EXPRESS it with greater probability. This is SIMILAR to the fact that X linked recessive DISORDER in mammals is expressed more in males.

63.

In XO system a male has a mother but not a _____________(a) Grand father(b) Father(c) Grand mother(d) SiblingThis question was addressed to me by my school principal while I was bunking the class.I'd like to ask this question from Other Methods of Sex Determination topic in division Chromosomes and Sex Determination of Cytogenetics

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Right option is (b) Father

Easy explanation: The MALES are produced by parthenogenesis, i.e. by mitosis. While fertilization only takes place in case of a FEMALE child, only the two X chromosomes COME TOGETHER. Thus, the male has a mother but no father; they do however have a grandfather.

64.

In case of XO system if an organism has AA+XO it will be a _______(a) Male(b) Neuter(c) Female(d) BisexualI have been asked this question in final exam.My question is from Other Methods of Sex Determination in chapter Chromosomes and Sex Determination of Cytogenetics

Answer» RIGHT answer is (a) MALE

Best explanation: In XO system presence of one COPY of X CHROMOSOME produces a male, while there is no Y chromosome. Two copies GIVE a female.
65.

Lysonization takes place ____________(a) 7^th day after fertilization(b) 15^th day after fertilization(c) 1^st month after fertilization(d) 6^th month after fertilizationI got this question in final exam.I need to ask this question from Dosage Compensation Mechanism for X linked Genes topic in portion Chromosomes and Sex Determination of Cytogenetics

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Right option is (B) 15^th day after fertilization

For explanation I would SAY: Lysonization process takes place in the 15^th day after fertilization when the EMBRYO is 500-1000 CELL STAGE. This inactivated one X chromosome in each cell.

66.

Choose the odd one out.(a) Color blindness(b) Haemophilia(c) Duchenne muscular dystrophy(d) Faulty tooth enamelI have been asked this question in an interview.Asked question is from Sex Linked Inheritance topic in chapter Chromosomes and Sex Determination of Cytogenetics

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The correct OPTION is (d) Faulty tooth ENAMEL

For explanation I would say: While the first three diseases are X linked recessive diseases, the last i.e. faulty tooth enamel and decolonization is a dominant TRAIT.

67.

In yeast the gene responsible for sex determination is ______________(a) SXL(b) XCE(c) MAT(d) XISTI have been asked this question in semester exam.Origin of the question is Other Methods of Sex Determination in portion Chromosomes and Sex Determination of Cytogenetics

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Right answer is (c) MAT

To EXPLAIN: In yeast, the GENES at the MAT locus are responsible for determining the SEX. Sex is mainly determined as mating FACTOR and it alternates with every generation.

68.

If A is a sex influenced trait that is more expressed in males, then which of the following is false?(a) Only male having a homozygous recessive form of this gene will not express it(b) No female will express the gene(c) The gene is autosomal(d) Heterozygous female will not express this geneI got this question by my school teacher while I was bunking the class.The query is from Sex Influenced Traits and Sex Limited Traits in portion Chromosomes and Sex Determination of Cytogenetics

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Correct OPTION is (b) No female will express the gene

The best EXPLANATION: If the sex influenced trait is more expressed in MEN then it ACTS as a dominant trait in men. And at the same time, it acts as a recessive trait in female. The female with homozygous form of this trait will thus express it, and men LACKING any copy of it in case of recessive homozygote will not express it.

69.

The sex influenced traits are present in _______________________(a) Autosome(b) Sex chromosome(c) Mitochondrial chromosome(d) These are epigenetic traitsThis question was posed to me during an online exam.The question is from Sex Influenced Traits and Sex Limited Traits in section Chromosomes and Sex Determination of Cytogenetics

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The correct option is (a) Autosome

Easy explanation: Sex INFLUENCED TRAITS are present in the autosomes. They are not present in the sex CHROMOSOME; ALTHOUGH their expression is DEPENDENT on the sex of the individual.

70.

We will see ZZ/ZW system in chicken; state true or false.(a) True(b) FalseI have been asked this question in quiz.The question is from Other Methods of Sex Determination topic in section Chromosomes and Sex Determination of Cytogenetics

Answer» CORRECT option is (a) True

Explanation: ZZ/ZW system is seen in BIRDS, chicken being a BIRD also follows this system. Mammals and insects have other system of gene DETERMINATION.
71.

Which of the following is a Y linked gene?(a) Faulty dental enamel(b) Haemophilia(c) Hypertrichosis(d) Phenyl ketone ureaI got this question during an online interview.This interesting question is from Sex Linked Inheritance topic in section Chromosomes and Sex Determination of Cytogenetics

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Right answer is (c) Hypertrichosis

Easy explanation: Among the following options only hypertrichosis is a Y linked gene. It is the presence of HAIR in the ear. It FOLLOWS the Y linked RULE of INHERITANCE.

72.

If colorblindness was a dominant trait, which of the following would not be true?(a) It would be expressed in heterozygous females(b) It would be expressed in males(c) It would never be turned off(d) It would not skip generationsI got this question by my college director while I was bunking the class.My question is taken from Sex Linked Inheritance in chapter Chromosomes and Sex Determination of Cytogenetics

Answer» RIGHT option is (c) It would never be turned off

To explain: DUE to dosage compensation X chromosomes are randomly turned off, so the MUTANT X could as WELL be turned off in heterozygote. Also it will affect every generation as it would be dominant. Option a and B are also true.
73.

In an experiment, you add the short arm of Y chromosome to a cell line with composition AA+ XX. What will you see?(a) The cell rejects the Y chromosome(b) The cell develop female character(c) The cell develop male character(d) The cell develop neuter gender characterI have been asked this question in an online interview.My question is from Sex Determination in Mammals in section Chromosomes and Sex Determination of Cytogenetics

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The correct answer is (c) The cell DEVELOP male character

Easiest explanation: The SHORT arm of the Y CHROMOSOME is carrying the SRY gene which DETERMINES the sex of the organism. Thus introduction of Y chromosome will promote the development of male characters.

74.

Which of the following is the correct pathway for developing female characters?(a) Sxl- SR- Tra- Dsx- Male gene repression(b) Sxl- Tra- SR- Dsx- Male gene repression(c) Sxl- Tra- Dsx- SR- Male gene repression(d) Sxl- SR- Dsx- Tra- Male gene repressionThis question was posed to me in an online quiz.Origin of the question is Sex Determination in Drosophila topic in portion Chromosomes and Sex Determination of Cytogenetics

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Right OPTION is (b) SXL- Tra- SR- Dsx- MALE gene repression

For explanation: Functional Sxl PROTEINS, controls the splicing of tra gene and produces functional Tra protein. Tra INTERACTS with SR proteins controlling splicing of Dsx giving female specific DsxF which ultimately represses male specific characters.

75.

Genetic combination of AA : XYY in drosophila gives a _________(a) Female(b) Non-viable female(c) Male(d) Non-viable maleI got this question in exam.My question is from Sex Determination in Drosophila in division Chromosomes and Sex Determination of Cytogenetics

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Correct choice is (C) Male

Explanation: In this combination the X: A ratio is o.5 which will PRODUCE a male. ALTHOUGH there will be some PROBLEM in disjunction and male gamete PRODUCTION, otherwise the male is perfectly viable.