InterviewSolution

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101.	Neurofibrillary tangles, found in the brain cells of persons with neurodegenerative disorders consists of _______________(a) intermediate filaments(b) microtubule-associated proteins(c) microtubules(d) phospholipidsI had been asked this question during an internship interview.Question is taken from Cytoskeleton topic in division Cytoskeleton and Cell Motility of Cell Biology
Answer» Correct choice is (b) microtubule-associated proteins For explanation I would SAY: Neurofibrillary TANGLES found in the brain CELLS of neurodegenerative diseases’ patients consists of tangled filaments of EXCESSIVELY phosphorylated ‘tau’ molecules. Tau molecules are a TYPE of MAPs (microtubule-associated proteins).

102.	Unlike other cytoskeletal elements, in the assembly of intermediate filaments there is no requirement of ______________(a) ATP/ GDP(b) Nucleation(c) Reduction(d) HydrolysisThis question was posed to me by my school teacher while I was bunking the class.The query is from Cytoskeleton in section Cytoskeleton and Cell Motility of Cell Biology
Answer» Correct CHOICE is (a) ATP/ GDP Easy explanation: UNLIKE microtubules and microfilaments, in the assembly STEPS of intermediate filaments there is no direct INVOLVEMENT of ATP or GDP.

103.	The drug colchicine promotes microtubule _____________(a) disassembly(b) assembly(c) acidification(d) condensationThis question was posed to me in an interview for internship.I want to ask this question from Cytoskeleton in portion Cytoskeleton and Cell Motility of Cell Biology
Answer» The correct CHOICE is (a) disassembly The explanation is: DRUGS like nocodazole and colchicine promote the disassembly of microtubules. As a result of this disassembly, the Golgi complex ORIGINALLY located near the nucleus (CENTER) is dispersed into peripheral region.

104.	Outer microtubules in a cilium are generated from ______________(a) basal body(b) centromere(c) centrosome(d) nucleusThis question was addressed to me during an online interview.I would like to ask this question from Cytoskeleton topic in portion Cytoskeleton and Cell Motility of Cell Biology
Answer» The correct answer is (a) BASAL body The explanation is: The outer microtubules in cilia are generated from the microtubules CALLED a basal body. The basal body resides at the BASE of the cilium and these are IDENTICAL to centrioles.

105.	In total internal reflection microscopy (TIRF), thin planes can be focused(a) True(b) FalseThe question was asked in unit test.My question is taken from Studying the Cytoskeleton in chapter Cytoskeleton and Cell Motility of Cell Biology
Answer» Right answer is (a) True Easiest explanation: Total internal reflection microscopy (TIRF) is a specialized type of laser-based fluorescence microscopy, which allows the focusing of very thin planes. As a result, FLUORESCENT light RAYS emanating from the field of view do not obscure the SPECIFIC PROTEINS being MONITORED.

106.	Microtubules of a dividing cell form the mitotic spindle.(a) True(b) FalseI got this question in an internship interview.This intriguing question comes from The Cytoskeleton in division Cytoskeleton and Cell Motility of Cell Biology
Answer» RIGHT choice is (a) True The BEST I can explain: Microtubules of a dividing cell FORM the mitotic spindle required for chromosome segregation. Microtubules in the nerve and epithelial cells play a ROLE in organelle TRANSPORT.

107.	Microtubules are formed of the protein ____________(a) clathrin(b) keratin(c) tubulin(d) actinThe question was asked in unit test.This is a very interesting question from The Cytoskeleton in portion Cytoskeleton and Cell Motility of Cell Biology
Answer» Correct answer is (C) TUBULIN To EXPLAIN: The cytoskeleton element, microtubules are LONG, hollow and unbranched polymer tubes composed of the PROTEIN tubulin.

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