Administration of general anesthetics decreases the presynaptic Ca^2+ entry.(a) True(b) FalseThe question was posed to me in examination.My question is based upon Mechanism of Action of General Anesthetics topic in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

Administration of general anesthetics decreases the presynaptic Ca^2+

1.	Administration of general anesthetics decreases the presynaptic Ca^2+ entry.(a) True(b) FalseThe question was posed to me in examination.My question is based upon Mechanism of Action of General Anesthetics topic in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology
Answer» RIGHT choice is (a) True For EXPLANATION I would say: Administration of general anesthetics decreases the presynaptic Ca^2+ entry, thus decreases the NEUROTRANSMITTER release. It INCREASES postsynaptic Cl^– entry and also increases postsynaptic K^+ leakage from the cell. Local anesthetics help block conduction. It decreases the axonal Na+ entry thus prevents ACTION potential propagation.

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