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Gaucher disease is caused due to deficiency of ______________(a) hexosaminidase A(b) lysosomes(c) glucocerebrosidase(d) mannose phophateThis question was addressed to me in an interview for job.The question is from Cytoplasmic Membrane Systems topic in section Cytoplasmic Membrane Systems of Cell Biology

Answer»

The correct choice is (C) glucocerebrosidase

The EXPLANATION is: Gaucher’s disease is caused by the DEFICIENCY of the lysosomal enzyme glucocerebrosidase. DUE to this deficiency, large quantities of glucocerebroside accumulate in the lysosomes of MACROPHAGES.



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