In a synergistic model of initiation which of the following factor doesn’t directly lead to initiation?(a) eIF4E(b) PAB1(c) eIF4G(d) Protein XThe question was posed to me during an online interview.The origin of the question is Control of Translation in chapter Gene Expression : Translation of Cytogenetics

In a synergistic model of initiation which of the following factor doe

1.	In a synergistic model of initiation which of the following factor doesn’t directly lead to initiation?(a) eIF4E(b) PAB1(c) eIF4G(d) Protein XThe question was posed to me during an online interview.The origin of the question is Control of Translation in chapter Gene Expression : Translation of Cytogenetics
Answer» CORRECT CHOICE is (d) PROTEIN X The best I can explain: In a synergistic model of INITIATION both the poly a TAIL and the G cap plays a role. So, PAB1 binds to the poly A tail and eIF4E binds to the 5’-G cap with the eIF4G acting as a linker. But protein X plays a role in IRES mode of initiation not this.

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