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Which of the following will effectively cause normal translation from an initiation AUG, blocked by a strong AUG upstream?(a) Hairpin loop near the 1^st AUG(b) No measure required(c) In frame stop codon between two AUGs(d) Deletion of the GAP between the two AUGsI had been asked this question in an online quiz.Origin of the question is Translation in Eukaryotes in portion Gene Expression : Translation of Cytogenetics

Answer»

Right OPTION is (C) In FRAME stop codon between two AUGs

For explanation: If there is in frame stop codon to 1^st AUG there will be an OPEN reading frame in between 1st AUG and stop codon and again another open reading frame from 2^nd AUG. This will lead to EFFECTIVELY normal translation from the 2^nd AUG.



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